Also indexed as: Apo-Metoclop, Gastrobid Continuous,
Gastroflux, Gastromax, Maxeran, Nu-Metoclopramide, Ocatmide, Parmid, PMS-Metoclopramide,
Metoclopramide is used to treat heartburn
and regurgitation; to prevent vomiting in people receiving drugs to treat cancer; and to
prevent nausea, vomiting, heartburn, and fullness after a meal in certain individuals with diabetes.
Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
| May Be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results.
|Depletion or interference
|Side effect reduction/prevention
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
Interactions with Dietary Supplements
A single case report described a 15-year-old girl who suffered oxygen deprivation in her body
tissues after being given high amounts of metoclopramide and N-acetyl-cysteine to treat her
for an overdose of paracetamol.1 It
is unknown whether N-acetyl-cysteine supplementation in the absence of paracetamol overdose
could cause similar effects in people taking metoclopramide. Until controlled research
determines the safety of this combination, it should be used only under the supervision of a
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Interactions with Herbs
Salicylic acid is a compound formed in the body from either aspirin or willow bark. Taking metoclopramide before
aspirin or willow bark results in higher concentrations of salicylic acid and greater pain
relief in people suffering from an acute migraine headache.2 Controlled studies are
necessary to confirm the benefit of this interaction.
Interaction with Foods and Other Compounds –––
Individuals who have lactose intolerance
(difficulty digesting milk sugar) may experience more severe symptoms while taking
metoclopramide.3 Lactose is the milk sugar present in dairy products.
A single case report described a 42-year-old man taking metoclopramide who experienced mental
depression after he abruptly quit using
caffeine.4 People who are advised to quit caffeine should probably reduce their
coffee or tea consumption gradually if they are taking metoclopramide.
Drinking alcohol while taking metoclopramide may significantly increase the amount and speed
of alcohol absorption, resulting in enhanced alcohol effects such as drowsiness.5
Consequently, people taking metoclopramide should avoid alcohol, especially when staying alert
1. Langford JS, Sheikh S. An adolescent case of sulfhemoglobinemia
associated with high-dose metoclopramide and N-acetylcysteine. Ann Emerg Med
2. Miner JO. Drug interactions involving aspirin (acetylsalicylic acid)
and salicylic acid. Clin Pharmacokinet 1989;17:327–44.
3. Peuhkuri K, Vapaatalo H, Nevala R, Korpela R. Influence of the
pharmacological modification of gastric emptying on lactose digestion and gastrointestinal
symptoms. Aliment Pharmacol Ther 1999;13:81–6.
4. Wenokur B, Lessem P. Caffeine withdrawal metoclopramide, and
depression. Am J Gastroenterol 1993;88:1464 [letter].
5. Sifton DW, ed. Physicians Desk Reference. Montvale,
NJ: Medical Economics Company, Inc., 2000, 2603–5.
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with Vitamins and Herbs
The information presented in Aisle7 is for informational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience,
or traditional usage as cited in each article. The results reported may not necessarily occur
in all individuals. For many of the conditions discussed, treatment with prescription or over
the counter medication is also available. Consult your doctor, practitioner, and/or chemist
for any health problem and before using any supplements or before making any changes in